Peptide receptor radionuclide therapy in neuroendocrine neoplasms and related tumors: from fundamentals to personalization and the newer experimental approaches
نویسندگان
چکیده
Introduction Peptide Receptor Radionuclide Therapy (PRRT) is a type of molecular-targeted endo-radionuclide therapy in which unsealed radiolabelled somatostatin analogues are specifically directed toward receptors (SSTR) over-expressed Neuroendocrine Neoplasms (NEN) and related malignancies. This modality has witnessed benchmark growth over last decade symbolizes remarkable development precision oncology. The tumor selectivity excellent tolerability with minimal side effects make this one the preferred therapeutic options metastatic progressive NENs.Areas covered review deliberates upon fundamentals PRRT, its indications employment as for A few special scenarios based on our experiences expertise have also been mentioned. short discussion current advancements worldwide future directions included.Expert opinion SSTR-based PET PRRT now an established theranostic approach management NENs. Its spectrum expanded form Neo-Adjuvant-PRRT, Sandwich Chemo-PRRT, Duo-PRRT, Salvage-PRRT, Intra-arterial-PRRT. application to other SSTR-expressing tumors includes metastatic/inoperable medullary thyroid cancer, neural crest malignancies like pheochromocytomas-paragangliomas (PPGLs), Merkel cell carcinoma, radioiodine-refractory meningiomas. Though substantial prospective evidence still lacking, multidisciplinary team should adopt appropriate by using dual tracer imaging gatekeeper.
منابع مشابه
Joint guidance on peptide receptor radionuclide therapy in neuroendocrine tumors.
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ژورنال
عنوان ژورنال: Expert review of precision medicine and drug development
سال: 2023
ISSN: ['2380-8993']
DOI: https://doi.org/10.1080/23808993.2023.2211090